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Mutational load analysis of unrelated individuals

Evolutionary genetic models predict that the cumulative effect of rare deleterious mutations across the genome—known as mutational load burden—increases the susceptibility to complex disease. To test the mutational load burden hypothesis, we adopted a two-tiered approach: assessing the impact of who...

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Detalles Bibliográficos
Autores principales:	Howrigan, Daniel P, Simonson, Matthew A, Kamens, Helen M, Stephens, Sarah H, Wills, Amanda G, Ehringer, Marissa A, Keller, Matthew C, McQueen, Matthew B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287893/ https://www.ncbi.nlm.nih.gov/pubmed/22373138 http://dx.doi.org/10.1186/1753-6561-5-S9-S55

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