A gene-based approach for testing association of rare alleles

Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we applied a gene-based approach to the 200 simulated data sets of unrelated individuals. The t...

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Detalles Bibliográficos
Autores principales: Xu, Hongyan, George, Varghese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287909/
https://www.ncbi.nlm.nih.gov/pubmed/22373566
http://dx.doi.org/10.1186/1753-6561-5-S9-S7
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author Xu, Hongyan
George, Varghese
author_facet Xu, Hongyan
George, Varghese
author_sort Xu, Hongyan
collection PubMed
description Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we applied a gene-based approach to the 200 simulated data sets of unrelated individuals. The test can detect the association of some genes with multiple rare variants.
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spelling pubmed-32879092012-02-28 A gene-based approach for testing association of rare alleles Xu, Hongyan George, Varghese BMC Proc Proceedings Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we applied a gene-based approach to the 200 simulated data sets of unrelated individuals. The test can detect the association of some genes with multiple rare variants. BioMed Central 2011-11-29 /pmc/articles/PMC3287909/ /pubmed/22373566 http://dx.doi.org/10.1186/1753-6561-5-S9-S7 Text en Copyright ©2011 Xu and George; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Xu, Hongyan
George, Varghese
A gene-based approach for testing association of rare alleles
title A gene-based approach for testing association of rare alleles
title_full A gene-based approach for testing association of rare alleles
title_fullStr A gene-based approach for testing association of rare alleles
title_full_unstemmed A gene-based approach for testing association of rare alleles
title_short A gene-based approach for testing association of rare alleles
title_sort gene-based approach for testing association of rare alleles
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287909/
https://www.ncbi.nlm.nih.gov/pubmed/22373566
http://dx.doi.org/10.1186/1753-6561-5-S9-S7
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AT georgevarghese genebasedapproachfortestingassociationofrarealleles

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