A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma

BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy. However, therapeutic approaches are compli...

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Detalles Bibliográficos
Autores principales: Sampson, John H., Schmittling, Robert J., Archer, Gary E., Congdon, Kendra L., Nair, Smita K., Reap, Elizabeth A., Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Herndon, James E., Coan, April, McLendon, Roger E., Reardon, David A., Vredenburgh, James J., Bigner, Darell D., Mitchell, Duane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288003/
https://www.ncbi.nlm.nih.gov/pubmed/22383993
http://dx.doi.org/10.1371/journal.pone.0031046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288003/
https://www.ncbi.nlm.nih.gov/pubmed/22383993
http://dx.doi.org/10.1371/journal.pone.0031046

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