Cargando…

Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells

Peritoneal fibrosis is a frequent complication of peritoneal dialysis following repeated low grade inflammatory and pro-fibrotic insults. This pathological process may lead to ultrafiltration failure and eventually to the discontinuing of the therapy. Fibrosis is linked to epithelial to mesenchymal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strippoli, Raffaele, Benedicto, Ignacio, Perez Lozano, Maria Luisa, Pellinen, Teijo, Sandoval, Pilar, Lopez-Cabrera, Manuel, del Pozo, Miguel Angel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288041/ https://www.ncbi.nlm.nih.gov/pubmed/22384029 http://dx.doi.org/10.1371/journal.pone.0031492

Ejemplares similares

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis
por: Strippoli, Raffaele, et al.
Publicado: (2015)

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis
por: Strippoli, Raffaele, et al.
Publicado: (2015)

Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis
por: Strippoli, Raffaele, et al.
Publicado: (2020)

Ovarian Cancer-Driven Mesothelial-to-Mesenchymal Transition is Triggered by the Endothelin-1/β-arr1 Axis
por: Del Rio, Danila, et al.
Publicado: (2021)

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
por: Rossi, Lucia, et al.
Publicado: (2018)

Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1)
por: Zhao, Jun-Li, et al.
Publicado: (2019)

Tamoxifen Ameliorates Peritoneal Membrane Damage by Blocking Mesothelial to Mesenchymal Transition in Peritoneal Dialysis
por: Loureiro, Jesús, et al.
Publicado: (2013)

Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
por: Bontempi, Giulio, et al.
Publicado: (2022)

The Mesothelial Origin of Carcinoma Associated-Fibroblasts in Peritoneal Metastasis
por: Rynne-Vidal, Angela, et al.
Publicado: (2015)

Mesothelial‐to‐mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer
por: Rynne‐Vidal, Angela, et al.
Publicado: (2017)

Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
por: Pascual-Antón, Lucía, et al.
Publicado: (2021)

Functional Relevance of the Switch of VEGF Receptors/Co-Receptors during Peritoneal Dialysis-Induced Mesothelial to Mesenchymal Transition
por: Pérez-Lozano, María Luisa, et al.
Publicado: (2013)

TAK1ng control: TAK1 restrains NLRP3 activation
por: Mangan, Matthew Stephen, et al.
Publicado: (2018)

TAK1 regulates Paneth cell integrity partly through blocking necroptosis
por: Simmons, A N, et al.
Publicado: (2016)

Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients
por: Ruiz-Carpio, Vicente, et al.
Publicado: (2017)

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer
por: Virtakoivu, Reetta, et al.
Publicado: (2012)

ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer
por: Pellinen, Teijo, et al.
Publicado: (2018)

Mesothelial-to-Mesenchymal Transition Contributes to the Generation of Carcinoma-Associated Fibroblasts in Locally Advanced Primary Colorectal Carcinomas
por: Gordillo, Carlos H., et al.
Publicado: (2020)

SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer
por: Magistri, Paolo, et al.
Publicado: (2018)

Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy
por: Sun, Kai, et al.
Publicado: (2023)

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins
por: Pellinen, Teijo, et al.
Publicado: (2006)

Tripartite Motif‐Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β–Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation
por: Chen, San‐Yang, et al.
Publicado: (2021)

A Nanoconjugate Apaf-1 Inhibitor Protects Mesothelial Cells from Cytokine-Induced Injury
por: Santamaría, Beatriz, et al.
Publicado: (2009)

Pleural Mesothelial Cells Modulate the Inflammatory/Profibrotic Response During SARS-CoV-2 Infection
por: Matusali, Giulia, et al.
Publicado: (2021)

Multifaceted Roles of TAK1 Signaling in Cancer
por: Mukhopadhyay, Himadri, et al.
Publicado: (2019)

Lesion of Aggregated Monocytes and Mesothelial Cells: Mesothelial/Monocytic Incidental Cardiac Lesion
por: Erinanç, Hilal, et al.
Publicado: (2013)

The Aurora Kinase Inhibitor TAK901 Inhibits Glioblastoma Growth by Blocking SREBP1-Mediated Lipid Metabolism
por: Zhan, Xiudan, et al.
Publicado: (2022)

The Novel Oral mTORC1/2 Inhibitor TAK-228 Reverses Trastuzumab Resistance in HER2-Positive Breast Cancer Models
por: Sanz-Álvarez, Marta, et al.
Publicado: (2021)

Carbon Nanotubes and Other Engineered Nanoparticles Induced Pathophysiology on Mesothelial Cells and Mesothelial Membranes
por: Sinis, Sotirios I., et al.
Publicado: (2018)

Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway
por: Yue, Xue-Jing, et al.
Publicado: (2022)

TAK1 is an essential regulator of BMP signalling in cartilage
por: Shim, Jae-Hyuck, et al.
Publicado: (2009)

Post-Translational Modifications of the TAK1-TAB Complex
por: Hirata, Yusuke, et al.
Publicado: (2017)

Is TAK1 a Direct Upstream Kinase of AMPK?
por: Neumann, Dietbert
Publicado: (2018)

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma
por: Campolo, Michela, et al.
Publicado: (2020)

Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice
por: Sayama, Koji, et al.
Publicado: (2010)

FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NFκB pathway
por: Chen, Xi, et al.
Publicado: (2022)

Editorial: Mesothelial Physiology and Pathophysiology
por: Zarogiannis, Sotirios G.
Publicado: (2018)

Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment
por: Wang, Yuhan, et al.
Publicado: (2022)

Antibody-supervised deep learning for quantification of tumor-infiltrating immune cells in hematoxylin and eosin stained breast cancer samples
por: Turkki, Riku, et al.
Publicado: (2016)

Blocking Posttranslational Core Fucosylation Ameliorates Rat Peritoneal Mesothelial Cell Epithelial-Mesenchymal Transition
por: Li, Long-Kai, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_su42jj0j3pkuvr57e9culccpt7