Integrative Genomic Analysis Reveals Extended Germline Homozygosity with Lung Cancer Risk in the PLCO Cohort

Susceptibility to common cancers is multigenic resulting from low-to-high penetrance predisposition-factors and environmental exposure. Genomic studies suggest germline homozygosity as a novel low-penetrance factor contributing to common cancers. We hypothesized that long homozygous regions (tracts-...

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Detalles Bibliográficos
Autores principales: Orloff, Mohammed S., Zhang, Li, Bebek, Gurkan, Eng, Charis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288062/
https://www.ncbi.nlm.nih.gov/pubmed/22384118
http://dx.doi.org/10.1371/journal.pone.0031975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288062/
https://www.ncbi.nlm.nih.gov/pubmed/22384118
http://dx.doi.org/10.1371/journal.pone.0031975

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