Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds

Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced states, together with the structure of the C61S mutan...

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Detalles Bibliográficos
Autores principales: Gabrielsen, Mads, Beckham, Katherine S. H., Feher, Victoria A., Zetterström, Caroline E., Wang, Dai, Müller, Sylke, Elofsson, Mikael, Amaro, Rommie E., Byron, Olwyn, Roe, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288085/
https://www.ncbi.nlm.nih.gov/pubmed/22384182
http://dx.doi.org/10.1371/journal.pone.0032217

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