Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis

BACKGROUND: Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics (MD...

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Detalles Bibliográficos
Autores principales: Padhi, Aditya K., Kumar, Hirdesh, Vasaikar, Suhas V., Jayaram, Bhyravabhotla, Gomes, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288110/
https://www.ncbi.nlm.nih.gov/pubmed/22384259
http://dx.doi.org/10.1371/journal.pone.0032479

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