Oncolytic Poxvirus Armed with Fas Ligand Leads to Induction of Cellular Fas Receptor and Selective Viral Replication in FasR Negative Cancer

The TNF superfamily members including Fas ligand and TRAIL have been studied extensively for cancer therapy, including as components of gene therapy. We examined the use of FasL expression to achieve tumor selective replication of an oncolytic poxvirus (vFasL) and explored its biology and therapeuti...

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Detalles Bibliográficos
Autores principales: Sathaiah, Magesh, Thirunavukkarasu, Pragatheeshwar, O’Malley, Mark E., Kavanagh, Maihgan A., Ravindranathan, Roshni, Austin, Frances, Guo, Z. Sheng, Bartlett, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288301/
https://www.ncbi.nlm.nih.gov/pubmed/22116377
http://dx.doi.org/10.1038/cgt.2011.77

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288301/
https://www.ncbi.nlm.nih.gov/pubmed/22116377
http://dx.doi.org/10.1038/cgt.2011.77

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