Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

The genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis risk has commonly been attributed to HLA-DRB1 alleles. Yet controversy persists about the causal variants in HLA-DRB1 and the presence of independent effects elsewhere in the MHC. Using existing genome-wide...

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Detalles Bibliográficos
Autores principales: Raychaudhuri, Soumya, Sandor, Cynthia, Stahl, Eli A., Freudenberg, Jan, Lee, Hye-Soon, Jia, Xiaoming, Alfredsson, Lars, Padyukov, Leonid, Klareskog, Lars, Worthington, Jane, Siminovitch, Katherine A., Bae, Sang-Cheol, Plenge, Robert M., Gregersen, Peter K., de Bakker, Paul I.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288335/
https://www.ncbi.nlm.nih.gov/pubmed/22286218
http://dx.doi.org/10.1038/ng.1076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288335/
https://www.ncbi.nlm.nih.gov/pubmed/22286218
http://dx.doi.org/10.1038/ng.1076

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