mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons

mRNA for neuronal Bak (N-Bak), a splice variant of pro-apoptotic Bcl-2 family member Bak is expressed in the neurons. Surprisingly the endogeneous N-Bak protein cannot be demonstrated in the neurons, although the antibodies recognize N-Bak protein from in vitro translation or transiently transfected...

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Detalles Bibliográficos
Autores principales: Jakobson, M, Lintulahti, A, Arumäe, U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288346/
https://www.ncbi.nlm.nih.gov/pubmed/22297299
http://dx.doi.org/10.1038/cddis.2012.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288346/
https://www.ncbi.nlm.nih.gov/pubmed/22297299
http://dx.doi.org/10.1038/cddis.2012.4

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