Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas

To identify somatic mutations in paediatric diffuse intrinsic pontine gliomas (DIPGs), we performed whole genome sequencing of 7 DIPGs and matched germline DNA, and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem paediatric glioblastomas (non-BS-PGs). 78% of DIPGs and 22% of non-B...

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Autores principales: Wu, Gang, Broniscer, Alberto, McEachron, Troy A, Lu, Charles, Paugh, Barbara S, Becksfort, Jared, Qu, Chunxu, Ding, Li, Huether, Robert, Parker, Matthew, Zhang, Junyuan, Gajjar, Amar, Dyer, Michael A, Mullighan, Charles G, Gilbertson, Richard J, Mardis, Elaine R., Wilson, Richard K., Downing, James R, Ellison, David W, Zhang, Jinghui, Baker, Suzanne J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288377/
https://www.ncbi.nlm.nih.gov/pubmed/22286216
http://dx.doi.org/10.1038/ng.1102
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author Wu, Gang
Broniscer, Alberto
McEachron, Troy A
Lu, Charles
Paugh, Barbara S
Becksfort, Jared
Qu, Chunxu
Ding, Li
Huether, Robert
Parker, Matthew
Zhang, Junyuan
Gajjar, Amar
Dyer, Michael A
Mullighan, Charles G
Gilbertson, Richard J
Mardis, Elaine R.
Wilson, Richard K.
Downing, James R
Ellison, David W
Zhang, Jinghui
Baker, Suzanne J
author_facet Wu, Gang
Broniscer, Alberto
McEachron, Troy A
Lu, Charles
Paugh, Barbara S
Becksfort, Jared
Qu, Chunxu
Ding, Li
Huether, Robert
Parker, Matthew
Zhang, Junyuan
Gajjar, Amar
Dyer, Michael A
Mullighan, Charles G
Gilbertson, Richard J
Mardis, Elaine R.
Wilson, Richard K.
Downing, James R
Ellison, David W
Zhang, Jinghui
Baker, Suzanne J
author_sort Wu, Gang
collection PubMed
description To identify somatic mutations in paediatric diffuse intrinsic pontine gliomas (DIPGs), we performed whole genome sequencing of 7 DIPGs and matched germline DNA, and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem paediatric glioblastomas (non-BS-PGs). 78% of DIPGs and 22% of non-BS-PGs contained p.K27M mutation in H3F3A, encoding histone H3.3, or the related HIST1H3B, encoding histone H3.1. An additional 14% of non-BS-PGs had somatic p.G34R H3F3A mutations.
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spelling pubmed-32883772012-09-01 Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas Wu, Gang Broniscer, Alberto McEachron, Troy A Lu, Charles Paugh, Barbara S Becksfort, Jared Qu, Chunxu Ding, Li Huether, Robert Parker, Matthew Zhang, Junyuan Gajjar, Amar Dyer, Michael A Mullighan, Charles G Gilbertson, Richard J Mardis, Elaine R. Wilson, Richard K. Downing, James R Ellison, David W Zhang, Jinghui Baker, Suzanne J Nat Genet Article To identify somatic mutations in paediatric diffuse intrinsic pontine gliomas (DIPGs), we performed whole genome sequencing of 7 DIPGs and matched germline DNA, and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem paediatric glioblastomas (non-BS-PGs). 78% of DIPGs and 22% of non-BS-PGs contained p.K27M mutation in H3F3A, encoding histone H3.3, or the related HIST1H3B, encoding histone H3.1. An additional 14% of non-BS-PGs had somatic p.G34R H3F3A mutations. 2012-01-29 /pmc/articles/PMC3288377/ /pubmed/22286216 http://dx.doi.org/10.1038/ng.1102 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wu, Gang
Broniscer, Alberto
McEachron, Troy A
Lu, Charles
Paugh, Barbara S
Becksfort, Jared
Qu, Chunxu
Ding, Li
Huether, Robert
Parker, Matthew
Zhang, Junyuan
Gajjar, Amar
Dyer, Michael A
Mullighan, Charles G
Gilbertson, Richard J
Mardis, Elaine R.
Wilson, Richard K.
Downing, James R
Ellison, David W
Zhang, Jinghui
Baker, Suzanne J
Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas
title Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas
title_full Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas
title_fullStr Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas
title_full_unstemmed Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas
title_short Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas
title_sort somatic histone h3 alterations in paediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288377/
https://www.ncbi.nlm.nih.gov/pubmed/22286216
http://dx.doi.org/10.1038/ng.1102
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