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Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome
Enhanced mGluR5 function is causally associated with the pathophysiology of Fragile X Syndrome (FXS), a leading inherited cause of intellectual disability and autism. Here we provide evidence that altered mGluR5-Homer scaffolds contribute to mGluR5 dysfunction and phenotypes in the FXS mouse model,...
Autores principales: | Ronesi, Jennifer A., Collins, Katie A., Hays, Seth A., Tsai, Nien-Pei, Guo, Weirui, Birnbaum, Shari G., Hu, Jia-Hua, Worley, Paul F., Gibson, Jay R., Huber, Kimberly M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288402/ https://www.ncbi.nlm.nih.gov/pubmed/22267161 http://dx.doi.org/10.1038/nn.3033 |
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