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Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways

To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (P < 5 × 10(−8))....

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Autores principales: Stolk, Lisette, Perry, John RB, Chasman, Daniel I, He, Chunyan, Mangino, Massimo, Sulem, Patrick, Barbalic, Maja, Broer, Linda, Byrne, Enda M, Ernst, Florian, Esko, Tõnu, Franceschini, Nora, Gudbjartsson, Daniel F, Hottenga, Jouke-Jan, Kraft, Peter, McArdle, Patick F, Porcu, Eleonora, Shin, So-Youn, Smith, Albert V, van Wingerden, Sophie, Zhai, Guangju, Zhuang, Wei V, Albrecht, Eva, Alizadeh, Behrooz Z, Aspelund, Thor, Bandinelli, Stefania, Lauc, Lovorka Barac, Beckmann, Jacques S, Boban, Mladen, Boerwinkle, Eric, Broekmans, Frank J, Burri, Andrea, Campbell, Harry, Chanock, Stephen J, Chen, Constance, Cornelis, Marilyn C, Corre, Tanguy, Coviello, Andrea D, d’Adamo, Pio, Davies, Gail, de Faire, Ulf, de Geus, Eco JC, Deary, Ian J, Dedoussis, George VZ, Deloukas, Panagiotis, Ebrahim, Shah, Eiriksdottir, Gudny, Emilsson, Valur, Eriksson, Johan G, Fauser, Bart CJM, Ferreli, Liana, Ferrucci, Luigi, Fischer, Krista, Folsom, Aaron R, Garcia, Melissa E, Gasparini, Paolo, Gieger, Christian, Glazer, Nicole, Grobbee, Diederick E, Hall, Per, Haller, Toomas, Hankinson, Susan E, Hass, Merli, Hayward, Caroline, Heath, Andrew C, Hofman, Albert, Ingelsson, Erik, Janssens, A Cecile JW, Johnson, Andrew D, Karasik, David, Kardia, Sharon LR, Keyzer, Jules, Kiel, Douglas P, Kolcic, Ivana, Kutalik, Zoltán, Lahti, Jari, Lai, Sandra, Laisk, Triin, Laven, Joop SE, Lawlor, Debbie A, Liu, Jianjun, Lopez, Lorna M, Louwers, Yvonne V, Magnusson, Patrik KE, Marongiu, Mara, Martin, Nicholas G, Klaric, Irena Martinovic, Masciullo, Corrado, McKnight, Barbara, Medland, Sarah E, Melzer, David, Mooser, Vincent, Navarro, Pau, Newman, Anne B, Nyholt, Dale R, Onland-Moret, N. Charlotte, Palotie, Aarno, Paré, Guillaume, Parker, Alex N, Pedersen, Nancy L, Peeters, Petra HM, Pistis, Giorgio, Plump, Andrew S, Polasek, Ozren, Pop, Victor JM, Psaty, Bruce M, Räikkönen, Katri, Rehnberg, Emil, Rotter, Jerome I, Rudan, Igor, Sala, Cinzia, Salumets, Andres, Scuteri, Angelo, Singleton, Andrew, Smith, Jennifer A, Snieder, Harold, Soranzo, Nicole, Stacey, Simon N, Starr, John M, Stathopoulou, Maria G, Stirrups, Kathleen, Stolk, Ronald P, Styrkarsdottir, Unnur, Sun, Yan V, Tenesa, Albert, Thorand, Barbara, Toniolo, Daniela, Tryggvadottir, Laufey, Tsui, Kim, Ulivi, Sheila, van Dam, Rob M, van der Schouw, Yvonne T, van Gils, Carla H, van Nierop, Peter, Vink, Jacqueline M, Visscher, Peter M, Voorhuis, Marlies, Waeber, Gérard, Wallaschofski, Henri, Wichmann, H Erich, Widen, Elisabeth, Gent, Colette JM Wijnands-van, Willemsen, Gonneke, Wilson, James F, Wolffenbuttel, Bruce HR, Wright, Alan F, Yerges-Armstrong, Laura M, Zemunik, Tatijana, Zgaga, Lina, Zillikens, M. Carola, Zygmunt, Marek, Arnold, Alice M, Boomsma, Dorret I, Buring, Julie E., Crisponi, Laura, Demerath, Ellen W, Gudnason, Vilmundur, Harris, Tamara B, Hu, Frank B, Hunter, David J, Launer, Lenore J, Metspalu, Andres, Montgomery, Grant W, Oostra, Ben A, Ridker, Paul M, Sanna, Serena, Schlessinger, David, Spector, Tim D, Stefansson, Kari, Streeten, Elizabeth A, Thorsteinsdottir, Unnur, Uda, Manuela, Uitterlinden, André G, van Duijn, Cornelia M, Völzke, Henry, Murray, Anna, Murabito, Joanne M, Visser, Jenny A, Lunetta, Kathryn L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288642/
https://www.ncbi.nlm.nih.gov/pubmed/22267201
http://dx.doi.org/10.1038/ng.1051

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