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High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells

BACKGROUND: Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with chronic HBV infection taking clevudine. Moreover, the...

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Detalles Bibliográficos
Autores principales:	Jang, Yoon-Ok, Quan, Xianglan, Das, Ranjan, Xu, Shanhua, Chung, Choon-Hee, Ahn, Chan Mug, Baik, Soon-Koo, Kong, In Deok, Park, Kyu-Sang, Kim, Moon Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288815/ https://www.ncbi.nlm.nih.gov/pubmed/22230186 http://dx.doi.org/10.1186/1471-230X-12-4

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