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The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes

Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. Although most of the focus has been placed on their cardiovascular effects, both positive and negative,...

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Detalles Bibliográficos
Autores principales: Thomas, M. C., Jandeleit-Dahm, K. A., Tikellis, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289856/
https://www.ncbi.nlm.nih.gov/pubmed/22448165
http://dx.doi.org/10.1155/2012/456529
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author Thomas, M. C.
Jandeleit-Dahm, K. A.
Tikellis, C.
author_facet Thomas, M. C.
Jandeleit-Dahm, K. A.
Tikellis, C.
author_sort Thomas, M. C.
collection PubMed
description Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. Although most of the focus has been placed on their cardiovascular effects, both positive and negative, these agents also have significant renoprotective actions in the diabetic kidney. Over and above action on metabolic control and effects on blood pressure, PPAR agonists also appear to have independent effects on a number of critical pathways that are implicated in the development and progression of diabetic kidney disease, including oxidative stress, inflammation, hypertrophy, and podocyte function. This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.
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spelling pubmed-32898562012-03-23 The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes Thomas, M. C. Jandeleit-Dahm, K. A. Tikellis, C. PPAR Res Review Article Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. Although most of the focus has been placed on their cardiovascular effects, both positive and negative, these agents also have significant renoprotective actions in the diabetic kidney. Over and above action on metabolic control and effects on blood pressure, PPAR agonists also appear to have independent effects on a number of critical pathways that are implicated in the development and progression of diabetic kidney disease, including oxidative stress, inflammation, hypertrophy, and podocyte function. This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes. Hindawi Publishing Corporation 2012 2012-02-12 /pmc/articles/PMC3289856/ /pubmed/22448165 http://dx.doi.org/10.1155/2012/456529 Text en Copyright © 2012 M. C. Thomas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Thomas, M. C.
Jandeleit-Dahm, K. A.
Tikellis, C.
The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
title The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
title_full The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
title_fullStr The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
title_full_unstemmed The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
title_short The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes
title_sort renoprotective actions of peroxisome proliferator-activated receptors agonists in diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289856/
https://www.ncbi.nlm.nih.gov/pubmed/22448165
http://dx.doi.org/10.1155/2012/456529
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