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Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis
A protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific World Journal
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289904/ https://www.ncbi.nlm.nih.gov/pubmed/22454608 http://dx.doi.org/10.1100/2012/504905 |
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author | Ping, Liyan Platzer, Matthias Wen, Gaiping Delaroque, Nicolas |
author_facet | Ping, Liyan Platzer, Matthias Wen, Gaiping Delaroque, Nicolas |
author_sort | Ping, Liyan |
collection | PubMed |
description | A protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic analysis was performed to gain more insights into its evolution. The GC profile of the aah gene indicated that it was evolved from a low GC ancestor. Its stop codon usage was also different from the general pattern of Actinobacterial genomes. The phylogeny of dps-like proteins showed strong correlation with the phylogeny of host bacteria. A conserved genomic synteny was identified in some taxonomically related Actinobacteria, suggesting that the ancestor genes had incorporated into the genome before the divergence of Micrococcineae from other families. The aah gene had evolved new function but still retained the typical dodecameric structure. |
format | Online Article Text |
id | pubmed-3289904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Scientific World Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-32899042012-03-27 Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis Ping, Liyan Platzer, Matthias Wen, Gaiping Delaroque, Nicolas ScientificWorldJournal Research Article A protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic analysis was performed to gain more insights into its evolution. The GC profile of the aah gene indicated that it was evolved from a low GC ancestor. Its stop codon usage was also different from the general pattern of Actinobacterial genomes. The phylogeny of dps-like proteins showed strong correlation with the phylogeny of host bacteria. A conserved genomic synteny was identified in some taxonomically related Actinobacteria, suggesting that the ancestor genes had incorporated into the genome before the divergence of Micrococcineae from other families. The aah gene had evolved new function but still retained the typical dodecameric structure. The Scientific World Journal 2012-02-01 /pmc/articles/PMC3289904/ /pubmed/22454608 http://dx.doi.org/10.1100/2012/504905 Text en Copyright © 2012 Liyan Ping et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ping, Liyan Platzer, Matthias Wen, Gaiping Delaroque, Nicolas Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
title | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
title_full | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
title_fullStr | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
title_full_unstemmed | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
title_short | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
title_sort | coevolution of aah: a dps-like gene with the host bacterium revealed by comparative genomic analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289904/ https://www.ncbi.nlm.nih.gov/pubmed/22454608 http://dx.doi.org/10.1100/2012/504905 |
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