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Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma

Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes o...

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Detalles Bibliográficos
Autores principales: Malchenko, Sergey, Seftor, Elisabeth A., Nikolsky, Yuri, Hasegawa, Susan L., Kuo, Sean, Stevens, Jeff W., Poyarkov, Stas, Nikolskaya, Tatiana, Kucaba, Tamara, Wang, Min, Abdulkawy, Hakim, Casavant, Thomas, Morcuende, Jose, Buckwalter, Joseph, Hohl, Raymond, DeYoung, Barry, Kernstine, Kemp, Bonaldo, Maria de Fatima, Hendrix, Mary J. C., Soares, Marcelo B., Soares, Vera Maria F. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289931/
https://www.ncbi.nlm.nih.gov/pubmed/22448124
http://dx.doi.org/10.1155/2012/820254
Descripción
Sumario:Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.