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Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma
Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289931/ https://www.ncbi.nlm.nih.gov/pubmed/22448124 http://dx.doi.org/10.1155/2012/820254 |
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author | Malchenko, Sergey Seftor, Elisabeth A. Nikolsky, Yuri Hasegawa, Susan L. Kuo, Sean Stevens, Jeff W. Poyarkov, Stas Nikolskaya, Tatiana Kucaba, Tamara Wang, Min Abdulkawy, Hakim Casavant, Thomas Morcuende, Jose Buckwalter, Joseph Hohl, Raymond DeYoung, Barry Kernstine, Kemp Bonaldo, Maria de Fatima Hendrix, Mary J. C. Soares, Marcelo B. Soares, Vera Maria F. C. |
author_facet | Malchenko, Sergey Seftor, Elisabeth A. Nikolsky, Yuri Hasegawa, Susan L. Kuo, Sean Stevens, Jeff W. Poyarkov, Stas Nikolskaya, Tatiana Kucaba, Tamara Wang, Min Abdulkawy, Hakim Casavant, Thomas Morcuende, Jose Buckwalter, Joseph Hohl, Raymond DeYoung, Barry Kernstine, Kemp Bonaldo, Maria de Fatima Hendrix, Mary J. C. Soares, Marcelo B. Soares, Vera Maria F. C. |
author_sort | Malchenko, Sergey |
collection | PubMed |
description | Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases. |
format | Online Article Text |
id | pubmed-3289931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32899312012-03-23 Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma Malchenko, Sergey Seftor, Elisabeth A. Nikolsky, Yuri Hasegawa, Susan L. Kuo, Sean Stevens, Jeff W. Poyarkov, Stas Nikolskaya, Tatiana Kucaba, Tamara Wang, Min Abdulkawy, Hakim Casavant, Thomas Morcuende, Jose Buckwalter, Joseph Hohl, Raymond DeYoung, Barry Kernstine, Kemp Bonaldo, Maria de Fatima Hendrix, Mary J. C. Soares, Marcelo B. Soares, Vera Maria F. C. Sarcoma Research Article Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases. Hindawi Publishing Corporation 2012 2012-02-16 /pmc/articles/PMC3289931/ /pubmed/22448124 http://dx.doi.org/10.1155/2012/820254 Text en Copyright © 2012 Sergey Malchenko et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Malchenko, Sergey Seftor, Elisabeth A. Nikolsky, Yuri Hasegawa, Susan L. Kuo, Sean Stevens, Jeff W. Poyarkov, Stas Nikolskaya, Tatiana Kucaba, Tamara Wang, Min Abdulkawy, Hakim Casavant, Thomas Morcuende, Jose Buckwalter, Joseph Hohl, Raymond DeYoung, Barry Kernstine, Kemp Bonaldo, Maria de Fatima Hendrix, Mary J. C. Soares, Marcelo B. Soares, Vera Maria F. C. Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma |
title | Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma |
title_full | Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma |
title_fullStr | Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma |
title_full_unstemmed | Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma |
title_short | Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma |
title_sort | putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289931/ https://www.ncbi.nlm.nih.gov/pubmed/22448124 http://dx.doi.org/10.1155/2012/820254 |
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