Cargando…

Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response

Essential fatty acids cannot be synthesized de novo by mammals and need to be ingested either with the diet or through the use of supplements/functional foods to ameliorate cardiovascular prognosis. This review focus on the molecular targets of omega 3 fatty acids and conjugated linoleic acid, as pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Visioli, Francesco, Giordano, Elena, Nicod, Nathalie Marie, Dávalos, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289952/
https://www.ncbi.nlm.nih.gov/pubmed/22393325
http://dx.doi.org/10.3389/fphys.2012.00042
_version_ 1782224922801602560
author Visioli, Francesco
Giordano, Elena
Nicod, Nathalie Marie
Dávalos, Alberto
author_facet Visioli, Francesco
Giordano, Elena
Nicod, Nathalie Marie
Dávalos, Alberto
author_sort Visioli, Francesco
collection PubMed
description Essential fatty acids cannot be synthesized de novo by mammals and need to be ingested either with the diet or through the use of supplements/functional foods to ameliorate cardiovascular prognosis. This review focus on the molecular targets of omega 3 fatty acids and conjugated linoleic acid, as paradigmatic molecules that can be exploited both as nutrients and as pharmacological agents, especially as related to cardioprotection. In addition, we indicate novel molecular targets, namely microRNAs that might contribute to the observed biological activities of such essential fatty acids.
format Online
Article
Text
id pubmed-3289952
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-32899522012-03-05 Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response Visioli, Francesco Giordano, Elena Nicod, Nathalie Marie Dávalos, Alberto Front Physiol Physiology Essential fatty acids cannot be synthesized de novo by mammals and need to be ingested either with the diet or through the use of supplements/functional foods to ameliorate cardiovascular prognosis. This review focus on the molecular targets of omega 3 fatty acids and conjugated linoleic acid, as paradigmatic molecules that can be exploited both as nutrients and as pharmacological agents, especially as related to cardioprotection. In addition, we indicate novel molecular targets, namely microRNAs that might contribute to the observed biological activities of such essential fatty acids. Frontiers Research Foundation 2012-02-29 /pmc/articles/PMC3289952/ /pubmed/22393325 http://dx.doi.org/10.3389/fphys.2012.00042 Text en Copyright © 2012 Visioli, Giordano, Nicod and Dávalos. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Physiology
Visioli, Francesco
Giordano, Elena
Nicod, Nathalie Marie
Dávalos, Alberto
Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response
title Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response
title_full Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response
title_fullStr Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response
title_full_unstemmed Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response
title_short Molecular Targets of Omega 3 and Conjugated Linoleic Fatty Acids – “Micromanaging” Cellular Response
title_sort molecular targets of omega 3 and conjugated linoleic fatty acids – “micromanaging” cellular response
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289952/
https://www.ncbi.nlm.nih.gov/pubmed/22393325
http://dx.doi.org/10.3389/fphys.2012.00042
work_keys_str_mv AT visiolifrancesco moleculartargetsofomega3andconjugatedlinoleicfattyacidsmicromanagingcellularresponse
AT giordanoelena moleculartargetsofomega3andconjugatedlinoleicfattyacidsmicromanagingcellularresponse
AT nicodnathaliemarie moleculartargetsofomega3andconjugatedlinoleicfattyacidsmicromanagingcellularresponse
AT davalosalberto moleculartargetsofomega3andconjugatedlinoleicfattyacidsmicromanagingcellularresponse