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Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels

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Here, we describe a new mechanism by which glutamate (Glu) and trace metals reciprocally modulate activity of the Ca(v)2.3 channel by profoundly shifting its voltage-dependent gating. We show that zinc and copper, at physiologically relevant concentrations, occupy an extracellular binding site on th...

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Detalles Bibliográficos
Autores principales:	Shcheglovitov, Aleksandr, Vitko, Iuliia, Lazarenko, Roman M., Orestes, Peihan, Todorovic, Slobodan M., Perez-Reyes, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289959/ https://www.ncbi.nlm.nih.gov/pubmed/22371363 http://dx.doi.org/10.1085/jgp.201110699

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