Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)

Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression. Most kinase inhibitors interact with the ATP binding si...

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Detalles Bibliográficos
Autores principales: Jani, Krupa S., Dalafave, D.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290105/
https://www.ncbi.nlm.nih.gov/pubmed/22399850
http://dx.doi.org/10.4137/BBI.S8971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290105/
https://www.ncbi.nlm.nih.gov/pubmed/22399850
http://dx.doi.org/10.4137/BBI.S8971

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