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Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial
INTRODUCTION: Exercise may improve cancer outcomes. Neoadjuvant chemotherapy (NC) for breast cancer provides a unique setting to evaluate intervention effects. Treatments leading to decreased post-neoadjuvant Ki-67 levels, smaller tumor size, and higher pathologic response are associated with improv...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290117/ https://www.ncbi.nlm.nih.gov/pubmed/22399859 http://dx.doi.org/10.4137/BCBCR.S9221 |
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author | Rao, Roshni Cruz, Veronica Peng, Yan Harker-Murray, Amy Haley, Barbara B. Zhao, Hong Xie, Xian-Jin Euhus, David |
author_facet | Rao, Roshni Cruz, Veronica Peng, Yan Harker-Murray, Amy Haley, Barbara B. Zhao, Hong Xie, Xian-Jin Euhus, David |
author_sort | Rao, Roshni |
collection | PubMed |
description | INTRODUCTION: Exercise may improve cancer outcomes. Neoadjuvant chemotherapy (NC) for breast cancer provides a unique setting to evaluate intervention effects. Treatments leading to decreased post-neoadjuvant Ki-67 levels, smaller tumor size, and higher pathologic response are associated with improved survival and lower recurrence. This randomized, prospective pilot trial evaluates the feasibility of supervised exercise during NC for breast cancer. METHODS: Stage II-III, ER positive, cancer patients with BMI > 25 receiving NC were randomized to standard NC with supervised bootcamp (NC + BC) or NC alone. Ki-67, C-peptide, BMI, and tumor size were measured before chemotherapy and at time of surgery. RESULTS: There were no initial differences between groups in regards to tumor size, C-peptide, BMI, and Ki–67. The NC + BC (n = 5) group had a lower mean BMI at the conclusion of NC compared with those (n = 5) in the NC group (28.0 versus 35.8, P = 0.03). Final tumor size was 2.59 cm in the NC + BC group versus 3.16 cm for NC (P = 0.76) Mean Ki-67 for NC + BC was 7% versus 29% with NC (P = 0.14). C-peptide (ng/mL) was equivalent between the two groups (4.55 NC + BC versus 4.74 NC, P = 0.85). CONCLUSIONS: Adding a supervised exercise program to NC is feasible, decreases BMI, and may lead to lower Ki-67 levels and improved survival. |
format | Online Article Text |
id | pubmed-3290117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-32901172012-03-07 Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial Rao, Roshni Cruz, Veronica Peng, Yan Harker-Murray, Amy Haley, Barbara B. Zhao, Hong Xie, Xian-Jin Euhus, David Breast Cancer (Auckl) Original Research INTRODUCTION: Exercise may improve cancer outcomes. Neoadjuvant chemotherapy (NC) for breast cancer provides a unique setting to evaluate intervention effects. Treatments leading to decreased post-neoadjuvant Ki-67 levels, smaller tumor size, and higher pathologic response are associated with improved survival and lower recurrence. This randomized, prospective pilot trial evaluates the feasibility of supervised exercise during NC for breast cancer. METHODS: Stage II-III, ER positive, cancer patients with BMI > 25 receiving NC were randomized to standard NC with supervised bootcamp (NC + BC) or NC alone. Ki-67, C-peptide, BMI, and tumor size were measured before chemotherapy and at time of surgery. RESULTS: There were no initial differences between groups in regards to tumor size, C-peptide, BMI, and Ki–67. The NC + BC (n = 5) group had a lower mean BMI at the conclusion of NC compared with those (n = 5) in the NC group (28.0 versus 35.8, P = 0.03). Final tumor size was 2.59 cm in the NC + BC group versus 3.16 cm for NC (P = 0.76) Mean Ki-67 for NC + BC was 7% versus 29% with NC (P = 0.14). C-peptide (ng/mL) was equivalent between the two groups (4.55 NC + BC versus 4.74 NC, P = 0.85). CONCLUSIONS: Adding a supervised exercise program to NC is feasible, decreases BMI, and may lead to lower Ki-67 levels and improved survival. Libertas Academica 2012-02-01 /pmc/articles/PMC3290117/ /pubmed/22399859 http://dx.doi.org/10.4137/BCBCR.S9221 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. |
spellingShingle | Original Research Rao, Roshni Cruz, Veronica Peng, Yan Harker-Murray, Amy Haley, Barbara B. Zhao, Hong Xie, Xian-Jin Euhus, David Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial |
title | Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial |
title_full | Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial |
title_fullStr | Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial |
title_full_unstemmed | Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial |
title_short | Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial |
title_sort | bootcamp during neoadjuvant chemotherapy for breast cancer: a randomized pilot trial |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290117/ https://www.ncbi.nlm.nih.gov/pubmed/22399859 http://dx.doi.org/10.4137/BCBCR.S9221 |
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