Loss and Gain of Function in SERPINB11: An Example of a Gene under Selection on Standing Variation, with Implications for Host-Pathogen Interactions

Serine protease inhibitors (SERPINs) are crucial in the regulation of diverse biological processes including inflammation and immune response. SERPINB11, located in the 18q21 gene cluster, is a polymorphic gene/pseudogene coding for a non-inhibitory SERPIN. In a genome-wide scan for recent selection...

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Detalles Bibliográficos
Autores principales: Seixas, Susana, Ivanova, Nevyana, Ferreira, Zelia, Rocha, Jorge, Victor, Bruno L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290568/
https://www.ncbi.nlm.nih.gov/pubmed/22393410
http://dx.doi.org/10.1371/journal.pone.0032518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290568/
https://www.ncbi.nlm.nih.gov/pubmed/22393410
http://dx.doi.org/10.1371/journal.pone.0032518

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