Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death

Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic chara...

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Detalles Bibliográficos
Autores principales: Chi, Jingwei, Li, Li, Liu, Mujun, Tan, Jieqiong, Tang, Chengyuan, Pan, Qian, Wang, Danling, Zhang, Zhuohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290583/
https://www.ncbi.nlm.nih.gov/pubmed/22393412
http://dx.doi.org/10.1371/journal.pone.0032531

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