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The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis
Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol. Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-base...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290822/ https://www.ncbi.nlm.nih.gov/pubmed/22454764 http://dx.doi.org/10.1155/2012/161879 |
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author | Bethlehem, Carina Groenwold, Frouwke M. Buter, Hanneke Kingma, W. Peter Kuiper, Michael A. de Lange, Fellery Elbers, Paul Groen, Henk van Roon, Eric N. Boerma, E. Christiaan |
author_facet | Bethlehem, Carina Groenwold, Frouwke M. Buter, Hanneke Kingma, W. Peter Kuiper, Michael A. de Lange, Fellery Elbers, Paul Groen, Henk van Roon, Eric N. Boerma, E. Christiaan |
author_sort | Bethlehem, Carina |
collection | PubMed |
description | Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol. Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-based treatment protocol in comparison to historic controls. Results. 2 × 70 patients were included. The first day the PAC group had a significantly higher positive fluid balance in comparison to controls (6.1 ± 2.6 versus 3.8 ± 2.4 litre, P < 0.001). After 7 days the cumulative fluid balance in the PAC group was significantly lower than in controls (9.4 ± 7.4 versus 13 ± 7.6 litre, P = 0.001). Maximum dose of norepinephrine was significantly higher in the PAC group. Compared to controls this was associated with a significant reduction in ventilator and ICU days. Conclusions. Introduction of a PAC-based treatment protocol in sepsis changed the administration of fluid and vasopressors significantly. |
format | Online Article Text |
id | pubmed-3290822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32908222012-03-27 The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis Bethlehem, Carina Groenwold, Frouwke M. Buter, Hanneke Kingma, W. Peter Kuiper, Michael A. de Lange, Fellery Elbers, Paul Groen, Henk van Roon, Eric N. Boerma, E. Christiaan Crit Care Res Pract Clinical Study Objective. The pulmonary artery catheter (PAC) remains topic of debate. Despite abundant data, it is of note that many trials did not incorporate a treatment protocol. Methods. We retrospectively evaluated fluid balances and catecholamine doses in septic patients after the introduction of a PAC-based treatment protocol in comparison to historic controls. Results. 2 × 70 patients were included. The first day the PAC group had a significantly higher positive fluid balance in comparison to controls (6.1 ± 2.6 versus 3.8 ± 2.4 litre, P < 0.001). After 7 days the cumulative fluid balance in the PAC group was significantly lower than in controls (9.4 ± 7.4 versus 13 ± 7.6 litre, P = 0.001). Maximum dose of norepinephrine was significantly higher in the PAC group. Compared to controls this was associated with a significant reduction in ventilator and ICU days. Conclusions. Introduction of a PAC-based treatment protocol in sepsis changed the administration of fluid and vasopressors significantly. Hindawi Publishing Corporation 2012 2012-02-21 /pmc/articles/PMC3290822/ /pubmed/22454764 http://dx.doi.org/10.1155/2012/161879 Text en Copyright © 2012 Carina Bethlehem et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Bethlehem, Carina Groenwold, Frouwke M. Buter, Hanneke Kingma, W. Peter Kuiper, Michael A. de Lange, Fellery Elbers, Paul Groen, Henk van Roon, Eric N. Boerma, E. Christiaan The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
title | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
title_full | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
title_fullStr | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
title_full_unstemmed | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
title_short | The Impact of a Pulmonary-Artery-Catheter-Based Protocol on Fluid and Catecholamine Administration in Early Sepsis |
title_sort | impact of a pulmonary-artery-catheter-based protocol on fluid and catecholamine administration in early sepsis |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290822/ https://www.ncbi.nlm.nih.gov/pubmed/22454764 http://dx.doi.org/10.1155/2012/161879 |
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