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Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing

BACKGROUND/AIMS: Dietary protein deprivation during pregnancy causes hypertension in offspring when they become adults. This study examined if postnatal rearing had an effect on blood pressure and glomerular number in male rats whose mothers were fed either a control diet or a low protein diet. METH...

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Detalles Bibliográficos
Autores principales: Habib, Sabeen, Zhang, Qiuyu, Baum, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290837/
https://www.ncbi.nlm.nih.gov/pubmed/22470389
http://dx.doi.org/10.1159/000333477
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author Habib, Sabeen
Zhang, Qiuyu
Baum, Michel
author_facet Habib, Sabeen
Zhang, Qiuyu
Baum, Michel
author_sort Habib, Sabeen
collection PubMed
description BACKGROUND/AIMS: Dietary protein deprivation during pregnancy causes hypertension in offspring when they become adults. This study examined if postnatal rearing had an effect on blood pressure and glomerular number in male rats whose mothers were fed either a control diet or a low protein diet. METHODS: Neonates were cross fostered at 1 day of age to a different mother. After birth, all nursing and weaned rats were fed a control diet. Blood pressure and glomerular number were measured in adult offspring. RESULTS: Control rats cross fostered to another control mother had a lower blood pressure than low protein rats cross fostered to another low protein mother (133 ± 4 vs. 151 ± 4 mm Hg, p < 0.05) and a greater number of glomeruli (28,388 ± 989 vs. 25,045 ± 851, p < 0.05). Fostering pups from the 20% group to mothers that were fed a 6% diet during pregnancy did not cause hypertension or a reduction in the number of glomeruli. However, fostering the 6% group on to mothers that were fed a 20% protein diet during pregnancy resulted in normalization of the blood pressure and number of glomeruli. CONCLUSION: The hypertension and reduced glomerular number resulting from prenatal dietary protein deprivation can be normalized by improving the postnatal environment.
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spelling pubmed-32908372012-04-02 Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing Habib, Sabeen Zhang, Qiuyu Baum, Michel Nephron Extra Original Paper BACKGROUND/AIMS: Dietary protein deprivation during pregnancy causes hypertension in offspring when they become adults. This study examined if postnatal rearing had an effect on blood pressure and glomerular number in male rats whose mothers were fed either a control diet or a low protein diet. METHODS: Neonates were cross fostered at 1 day of age to a different mother. After birth, all nursing and weaned rats were fed a control diet. Blood pressure and glomerular number were measured in adult offspring. RESULTS: Control rats cross fostered to another control mother had a lower blood pressure than low protein rats cross fostered to another low protein mother (133 ± 4 vs. 151 ± 4 mm Hg, p < 0.05) and a greater number of glomeruli (28,388 ± 989 vs. 25,045 ± 851, p < 0.05). Fostering pups from the 20% group to mothers that were fed a 6% diet during pregnancy did not cause hypertension or a reduction in the number of glomeruli. However, fostering the 6% group on to mothers that were fed a 20% protein diet during pregnancy resulted in normalization of the blood pressure and number of glomeruli. CONCLUSION: The hypertension and reduced glomerular number resulting from prenatal dietary protein deprivation can be normalized by improving the postnatal environment. S. Karger AG 2011-10-25 /pmc/articles/PMC3290837/ /pubmed/22470389 http://dx.doi.org/10.1159/000333477 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Paper
Habib, Sabeen
Zhang, Qiuyu
Baum, Michel
Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing
title Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing
title_full Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing
title_fullStr Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing
title_full_unstemmed Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing
title_short Prenatal Programming of Hypertension in the Rat: Effect of Postnatal Rearing
title_sort prenatal programming of hypertension in the rat: effect of postnatal rearing
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290837/
https://www.ncbi.nlm.nih.gov/pubmed/22470389
http://dx.doi.org/10.1159/000333477
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