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Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes

Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rap...

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Autor principal: Mariappan, Meenalakshmi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290898/
https://www.ncbi.nlm.nih.gov/pubmed/22454628
http://dx.doi.org/10.1155/2012/749812
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author Mariappan, Meenalakshmi M.
author_facet Mariappan, Meenalakshmi M.
author_sort Mariappan, Meenalakshmi M.
collection PubMed
description Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rapamycin-)regulated pathways are pivotal in orchestrating high glucose-induced production of ECM proteins leading to functional and structural changes in the kidney culminating in adverse outcomes. Understanding signaling pathways that influence individual matrix protein expression could lead to the development of new interventional strategies. This paper will highlight some of the diverse components of the signaling network stimulated by hyperglycemia with an emphasis on extracellular matrix protein metabolism in the kidney in diabetes.
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spelling pubmed-32908982012-03-27 Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes Mariappan, Meenalakshmi M. Exp Diabetes Res Review Article Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rapamycin-)regulated pathways are pivotal in orchestrating high glucose-induced production of ECM proteins leading to functional and structural changes in the kidney culminating in adverse outcomes. Understanding signaling pathways that influence individual matrix protein expression could lead to the development of new interventional strategies. This paper will highlight some of the diverse components of the signaling network stimulated by hyperglycemia with an emphasis on extracellular matrix protein metabolism in the kidney in diabetes. Hindawi Publishing Corporation 2012 2012-02-19 /pmc/articles/PMC3290898/ /pubmed/22454628 http://dx.doi.org/10.1155/2012/749812 Text en Copyright © 2012 Meenalakshmi M. Mariappan. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mariappan, Meenalakshmi M.
Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
title Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
title_full Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
title_fullStr Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
title_full_unstemmed Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
title_short Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
title_sort signaling mechanisms in the regulation of renal matrix metabolism in diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290898/
https://www.ncbi.nlm.nih.gov/pubmed/22454628
http://dx.doi.org/10.1155/2012/749812
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