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Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice

The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence. Substances were acutely (for expression) or repeatedl...

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Autores principales: Mattioli, Laura, Bracci, Antonio, Titomanlio, Federica, Perfumi, Marina, De Feo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290905/
https://www.ncbi.nlm.nih.gov/pubmed/22454681
http://dx.doi.org/10.1155/2012/741925
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author Mattioli, Laura
Bracci, Antonio
Titomanlio, Federica
Perfumi, Marina
De Feo, Vincenzo
author_facet Mattioli, Laura
Bracci, Antonio
Titomanlio, Federica
Perfumi, Marina
De Feo, Vincenzo
author_sort Mattioli, Laura
collection PubMed
description The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence. Substances were acutely (for expression) or repeatedly (for acquisition) administered in mice treated with morphine twice daily for 5 or 6 days, in order to make them tolerant or dependent. Morphine tolerance was assessed using the tail-flick test at 1st and 5th days. Morphine dependence was evaluated through the manifestation of withdrawal symptoms induced by naloxone injection at 6th day. Results showed that BRU significantly reduced the expression of morphine tolerance, while it was ineffective to modulate its acquisition. Chromatographic fractions and pure alkaloids failed to reduce morphine tolerance. Conversely BRU, FA, and pure alkaloids administrations significantly attenuated both development and expression of morphine dependence. These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction.
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spelling pubmed-32909052012-03-27 Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice Mattioli, Laura Bracci, Antonio Titomanlio, Federica Perfumi, Marina De Feo, Vincenzo Evid Based Complement Alternat Med Research Article The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence. Substances were acutely (for expression) or repeatedly (for acquisition) administered in mice treated with morphine twice daily for 5 or 6 days, in order to make them tolerant or dependent. Morphine tolerance was assessed using the tail-flick test at 1st and 5th days. Morphine dependence was evaluated through the manifestation of withdrawal symptoms induced by naloxone injection at 6th day. Results showed that BRU significantly reduced the expression of morphine tolerance, while it was ineffective to modulate its acquisition. Chromatographic fractions and pure alkaloids failed to reduce morphine tolerance. Conversely BRU, FA, and pure alkaloids administrations significantly attenuated both development and expression of morphine dependence. These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction. Hindawi Publishing Corporation 2012 2012-02-08 /pmc/articles/PMC3290905/ /pubmed/22454681 http://dx.doi.org/10.1155/2012/741925 Text en Copyright © 2012 Laura Mattioli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mattioli, Laura
Bracci, Antonio
Titomanlio, Federica
Perfumi, Marina
De Feo, Vincenzo
Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
title Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
title_full Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
title_fullStr Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
title_full_unstemmed Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
title_short Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
title_sort effects of brugmansia arborea extract and its secondary metabolites on morphine tolerance and dependence in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290905/
https://www.ncbi.nlm.nih.gov/pubmed/22454681
http://dx.doi.org/10.1155/2012/741925
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