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Understanding the roles of gingival beta-defensins

Gingival epithelium produces β-defensins, small cationic peptides, as part of its contribution to the innate host defense against the bacterial challenge that is constantly present in the oral cavity. Besides their functions in healthy gingival tissues, β-defensins are involved in the initiation and...

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Detalles Bibliográficos
Autores principales: Gursoy, Ulvi Kahraman, Könönen, Eija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290911/
https://www.ncbi.nlm.nih.gov/pubmed/22389759
http://dx.doi.org/10.3402/jom.v4i0.15127
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author Gursoy, Ulvi Kahraman
Könönen, Eija
author_facet Gursoy, Ulvi Kahraman
Könönen, Eija
author_sort Gursoy, Ulvi Kahraman
collection PubMed
description Gingival epithelium produces β-defensins, small cationic peptides, as part of its contribution to the innate host defense against the bacterial challenge that is constantly present in the oral cavity. Besides their functions in healthy gingival tissues, β-defensins are involved in the initiation and progression, as well as restriction of periodontal tissue destruction, by acting as antimicrobial, chemotactic, and anti-inflammatory agents. In this article, we review the common knowledge about β-defensins, coming from in vivo and in vitro monolayer studies, and present new aspects, based on the experience on three-dimensional organotypic culture models, to the important role of gingival β-defensins in homeostasis of the periodontium.
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spelling pubmed-32909112012-03-02 Understanding the roles of gingival beta-defensins Gursoy, Ulvi Kahraman Könönen, Eija J Oral Microbiol Review Article Gingival epithelium produces β-defensins, small cationic peptides, as part of its contribution to the innate host defense against the bacterial challenge that is constantly present in the oral cavity. Besides their functions in healthy gingival tissues, β-defensins are involved in the initiation and progression, as well as restriction of periodontal tissue destruction, by acting as antimicrobial, chemotactic, and anti-inflammatory agents. In this article, we review the common knowledge about β-defensins, coming from in vivo and in vitro monolayer studies, and present new aspects, based on the experience on three-dimensional organotypic culture models, to the important role of gingival β-defensins in homeostasis of the periodontium. Co-Action Publishing 2012-02-28 /pmc/articles/PMC3290911/ /pubmed/22389759 http://dx.doi.org/10.3402/jom.v4i0.15127 Text en © 2012 Ulvi Kahraman Gursoy and Eija Könönen. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gursoy, Ulvi Kahraman
Könönen, Eija
Understanding the roles of gingival beta-defensins
title Understanding the roles of gingival beta-defensins
title_full Understanding the roles of gingival beta-defensins
title_fullStr Understanding the roles of gingival beta-defensins
title_full_unstemmed Understanding the roles of gingival beta-defensins
title_short Understanding the roles of gingival beta-defensins
title_sort understanding the roles of gingival beta-defensins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290911/
https://www.ncbi.nlm.nih.gov/pubmed/22389759
http://dx.doi.org/10.3402/jom.v4i0.15127
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