Cargando…
Active Cytomegalovirus Infection in Patients with Septic Shock
Cytomegalovirus (CMV) is a pathogen of emerging importance for patients with septic shock. In this prospective study, 25 immunocompetent CMV-seropositive patients with septic shock and an intensive care unit stay of >7 days were monitored by using quantitative pp65-antigenemia assay, shell vial c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290950/ https://www.ncbi.nlm.nih.gov/pubmed/17176565 http://dx.doi.org/10.3201/eid1210.060411 |
_version_ | 1782225072949297152 |
---|---|
author | von Müller, Lutz Klemm, Anke Weiss, Manfred Schneider, Marion Suger-Wiedeck, Heide Durmus, Nilgün Hampl, Walter Mertens, Thomas |
author_facet | von Müller, Lutz Klemm, Anke Weiss, Manfred Schneider, Marion Suger-Wiedeck, Heide Durmus, Nilgün Hampl, Walter Mertens, Thomas |
author_sort | von Müller, Lutz |
collection | PubMed |
description | Cytomegalovirus (CMV) is a pathogen of emerging importance for patients with septic shock. In this prospective study, 25 immunocompetent CMV-seropositive patients with septic shock and an intensive care unit stay of >7 days were monitored by using quantitative pp65-antigenemia assay, shell vial culture, and virus isolation. Within 2 weeks, active CMV infection with low-level pp65-antigenemia (median 3 positive/5 × 10(5) leukocytes) developed in 8 (32%) patients. Infection was controlled within a few weeks (median 26 days) without use of antiviral therapy. Duration of intensive care and mechanical ventilation were significantly prolonged in patients with active CMV infection. CMV reactivation was associated with concomitant herpes simplex virus reactivation (p = 0.004). The association between active CMV infection and increased illness could open new therapeutic options for patients with septic shock. Future interventional studies are required. |
format | Online Article Text |
id | pubmed-3290950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-32909502012-03-06 Active Cytomegalovirus Infection in Patients with Septic Shock von Müller, Lutz Klemm, Anke Weiss, Manfred Schneider, Marion Suger-Wiedeck, Heide Durmus, Nilgün Hampl, Walter Mertens, Thomas Emerg Infect Dis Research Cytomegalovirus (CMV) is a pathogen of emerging importance for patients with septic shock. In this prospective study, 25 immunocompetent CMV-seropositive patients with septic shock and an intensive care unit stay of >7 days were monitored by using quantitative pp65-antigenemia assay, shell vial culture, and virus isolation. Within 2 weeks, active CMV infection with low-level pp65-antigenemia (median 3 positive/5 × 10(5) leukocytes) developed in 8 (32%) patients. Infection was controlled within a few weeks (median 26 days) without use of antiviral therapy. Duration of intensive care and mechanical ventilation were significantly prolonged in patients with active CMV infection. CMV reactivation was associated with concomitant herpes simplex virus reactivation (p = 0.004). The association between active CMV infection and increased illness could open new therapeutic options for patients with septic shock. Future interventional studies are required. Centers for Disease Control and Prevention 2006-10 /pmc/articles/PMC3290950/ /pubmed/17176565 http://dx.doi.org/10.3201/eid1210.060411 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research von Müller, Lutz Klemm, Anke Weiss, Manfred Schneider, Marion Suger-Wiedeck, Heide Durmus, Nilgün Hampl, Walter Mertens, Thomas Active Cytomegalovirus Infection in Patients with Septic Shock |
title | Active Cytomegalovirus Infection in Patients with Septic Shock |
title_full | Active Cytomegalovirus Infection in Patients with Septic Shock |
title_fullStr | Active Cytomegalovirus Infection in Patients with Septic Shock |
title_full_unstemmed | Active Cytomegalovirus Infection in Patients with Septic Shock |
title_short | Active Cytomegalovirus Infection in Patients with Septic Shock |
title_sort | active cytomegalovirus infection in patients with septic shock |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290950/ https://www.ncbi.nlm.nih.gov/pubmed/17176565 http://dx.doi.org/10.3201/eid1210.060411 |
work_keys_str_mv | AT vonmullerlutz activecytomegalovirusinfectioninpatientswithsepticshock AT klemmanke activecytomegalovirusinfectioninpatientswithsepticshock AT weissmanfred activecytomegalovirusinfectioninpatientswithsepticshock AT schneidermarion activecytomegalovirusinfectioninpatientswithsepticshock AT sugerwiedeckheide activecytomegalovirusinfectioninpatientswithsepticshock AT durmusnilgun activecytomegalovirusinfectioninpatientswithsepticshock AT hamplwalter activecytomegalovirusinfectioninpatientswithsepticshock AT mertensthomas activecytomegalovirusinfectioninpatientswithsepticshock |