Azithromycin Failure in Mycoplasma genitalium Urethritis

We report significant failure rates (28%, 95% confidence interval 15%–45%) after administering 1 g azithromycin to men with Mycoplasma genitalium–positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted...

Descripción completa

Detalles Bibliográficos
Autores principales: Bradshaw, Catriona S., Jensen, Jorgen S., Tabrizi, Sepehr N., Read, Timothy R.H., Garland, Suzanne M., Hopkins, Carol A., Moss, Lorna M., Fairley, Christopher K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291056/
https://www.ncbi.nlm.nih.gov/pubmed/16836839
http://dx.doi.org/10.3201/eid1207.051558
Descripción
Sumario:We report significant failure rates (28%, 95% confidence interval 15%–45%) after administering 1 g azithromycin to men with Mycoplasma genitalium–positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis.

Ejemplares similares