Azithromycin Failure in Mycoplasma genitalium Urethritis

We report significant failure rates (28%, 95% confidence interval 15%–45%) after administering 1 g azithromycin to men with Mycoplasma genitalium–positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted...

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Detalles Bibliográficos
Autores principales: Bradshaw, Catriona S., Jensen, Jorgen S., Tabrizi, Sepehr N., Read, Timothy R.H., Garland, Suzanne M., Hopkins, Carol A., Moss, Lorna M., Fairley, Christopher K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291056/
https://www.ncbi.nlm.nih.gov/pubmed/16836839
http://dx.doi.org/10.3201/eid1207.051558
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author Bradshaw, Catriona S.
Jensen, Jorgen S.
Tabrizi, Sepehr N.
Read, Timothy R.H.
Garland, Suzanne M.
Hopkins, Carol A.
Moss, Lorna M.
Fairley, Christopher K.
author_facet Bradshaw, Catriona S.
Jensen, Jorgen S.
Tabrizi, Sepehr N.
Read, Timothy R.H.
Garland, Suzanne M.
Hopkins, Carol A.
Moss, Lorna M.
Fairley, Christopher K.
author_sort Bradshaw, Catriona S.
collection PubMed
description We report significant failure rates (28%, 95% confidence interval 15%–45%) after administering 1 g azithromycin to men with Mycoplasma genitalium–positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis.
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spelling pubmed-32910562012-03-05 Azithromycin Failure in Mycoplasma genitalium Urethritis Bradshaw, Catriona S. Jensen, Jorgen S. Tabrizi, Sepehr N. Read, Timothy R.H. Garland, Suzanne M. Hopkins, Carol A. Moss, Lorna M. Fairley, Christopher K. Emerg Infect Dis Dispatch We report significant failure rates (28%, 95% confidence interval 15%–45%) after administering 1 g azithromycin to men with Mycoplasma genitalium–positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis. Centers for Disease Control and Prevention 2006-07 /pmc/articles/PMC3291056/ /pubmed/16836839 http://dx.doi.org/10.3201/eid1207.051558 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Bradshaw, Catriona S.
Jensen, Jorgen S.
Tabrizi, Sepehr N.
Read, Timothy R.H.
Garland, Suzanne M.
Hopkins, Carol A.
Moss, Lorna M.
Fairley, Christopher K.
Azithromycin Failure in Mycoplasma genitalium Urethritis
title Azithromycin Failure in Mycoplasma genitalium Urethritis
title_full Azithromycin Failure in Mycoplasma genitalium Urethritis
title_fullStr Azithromycin Failure in Mycoplasma genitalium Urethritis
title_full_unstemmed Azithromycin Failure in Mycoplasma genitalium Urethritis
title_short Azithromycin Failure in Mycoplasma genitalium Urethritis
title_sort azithromycin failure in mycoplasma genitalium urethritis
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291056/
https://www.ncbi.nlm.nih.gov/pubmed/16836839
http://dx.doi.org/10.3201/eid1207.051558
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