Molecular Analysis of Fluoroquinolone-resistant Salmonella Paratyphi A Isolate, India

Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83→Phe and Asp87→Gly) and a mutation in topo...

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Detalles Bibliográficos
Autores principales: Nair, Satheesh, Unnikrishnan, Madhulika, Turner, Keith, Parija, Subash Chandra, Churcher, Carol, Wain, John, Harish, Belgode Narasimha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291429/
https://www.ncbi.nlm.nih.gov/pubmed/16704790
http://dx.doi.org/10.3201/eid1203.050560
Descripción
Sumario:Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83→Phe and Asp87→Gly) and a mutation in topoisomerase IV subunit parC (Ser80→Arg).

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