Protease-resistant Prion Protein in Lymphoreticular Tumors of Variant Creutzfeldt-Jakob Disease Mice

We report protease-resistant prion protein (PrP(res)) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). PrP(res) may accumulate in lymphoreticular system tumors of asymptomatic persons with vCJD. The statistical power of estimates of v...

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Detalles Bibliográficos
Autores principales: Cervenakova, Larisa, Yakovleva, Oksana, McKenzie, Carroll
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291462/
https://www.ncbi.nlm.nih.gov/pubmed/16704797
http://dx.doi.org/10.3201/eid1203.051348
Descripción
Sumario:We report protease-resistant prion protein (PrP(res)) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). PrP(res) may accumulate in lymphoreticular system tumors of asymptomatic persons with vCJD. The statistical power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms.

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