Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients

PURPOSE: To investigate whether interleukin 10 (IL10) gene polymorphisms are associated with the development of sarcoidosis in Japanese patients. METHODS: Two hundred and eighty-eight Japanese sarcoidosis patients and 310 Japanese healthy controls were recruited. We genotyped 9 single-nucleotide pol...

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Detalles Bibliográficos
Autores principales: Sakuyama, Kenichi, Meguro, Akira, Ota, Masao, Ishihara, Mami, Uemoto, Riyo, Ito, Haruyasu, Okada, Eiichi, Namba, Kenichi, Kitaichi, Nobuyoshi, Morimoto, Shin-ichiro, Kaburaki, Toshikatsu, Ando, Yasutaka, Takenaka, Shinobu, Yuasa, Takenosuke, Ohno, Shigeaki, Inoko, Hidetoshi, Mizuki, Nobuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291520/
https://www.ncbi.nlm.nih.gov/pubmed/22393278
Descripción
Sumario:PURPOSE: To investigate whether interleukin 10 (IL10) gene polymorphisms are associated with the development of sarcoidosis in Japanese patients. METHODS: Two hundred and eighty-eight Japanese sarcoidosis patients and 310 Japanese healthy controls were recruited. We genotyped 9 single-nucleotide polymorphisms in IL10 and assessed the allelic diversity between cases and controls. RESULTS: No significant differences in the frequency of IL10 alleles, genotypes, and haplotypes in the sarcoidosis cases compared to the controls were detected. CONCLUSIONS: Our results suggest that IL10 polymorphisms are not significantly related to the pathogenesis of sarcoidosis in the Japanese population.

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