Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts

PURPOSE: Due to its ability to disrupt transforming growth factor beta (TGF-β) signaling, halofuginone has been successfully used to treat various fibrotic disorders. Here we investigated the antifibrotic potential of halofuginone in human corneal fibroblasts. METHODS: Human corneal fibroblasts were...

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Detalles Bibliográficos
Autores principales: Nelson, Elizabeth F., Huang, Craig W., Ewel, Jillian M., Chang, Angela A., Yuan, Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291522/
https://www.ncbi.nlm.nih.gov/pubmed/22393274

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