Placement of Leucine Zipper Motifs at the Carboxyl Terminus of HIV-1 Protease Significantly Reduces Virion Production

Natural HIV-1 protease (PR) is homodimeric. Some researchers believe that interactions between HIV-1 Gag-Pol molecules trigger the activation of embedded PR (which mediates Gag and Gag-Pol cleavage), and that Gag-Pol assembly domains outside of PR may contribute to PR activation by influencing PR di...

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Detalles Bibliográficos
Autores principales: Pan, Yen-Yu, Wang, Shiu-Mei, Huang, Kuo-Jung, Chiang, Chien-Cheng, Wang, Chin-Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291649/
https://www.ncbi.nlm.nih.gov/pubmed/22396796
http://dx.doi.org/10.1371/journal.pone.0032845

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