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A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials
The contribution of stem cells to cure damaged hearts has finally been unraveled. A large number of preclinical and clinical studies have showed beneficial outcomes after myocardial infarction. In this review, the current understanding of stem cell therapy in preclinical and clinical experiences is...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Cardiology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291729/ https://www.ncbi.nlm.nih.gov/pubmed/22396692 http://dx.doi.org/10.4070/kcj.2012.42.2.71 |
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author | Kim, Yong Sook Ahn, Youngkeun |
author_facet | Kim, Yong Sook Ahn, Youngkeun |
author_sort | Kim, Yong Sook |
collection | PubMed |
description | The contribution of stem cells to cure damaged hearts has finally been unraveled. A large number of preclinical and clinical studies have showed beneficial outcomes after myocardial infarction. In this review, the current understanding of stem cell therapy in preclinical and clinical experiences is summarized. Stem cells from bone marrow have shown a potential to improve cardiac performance after myocardial infarction in animal and early clinical studies. Clinical trials from all over the world have provided safety assessments of stem cell therapy with marginal improvement of clinical outcomes. Thus, further investigations should be encouraged to resolve the discrepancies between studies, clinical issues, and unclear translational findings. This review provides information and commentary on key trials for stem cell-based treat-ment of cardiovascular disease. |
format | Online Article Text |
id | pubmed-3291729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32917292012-03-06 A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials Kim, Yong Sook Ahn, Youngkeun Korean Circ J Review The contribution of stem cells to cure damaged hearts has finally been unraveled. A large number of preclinical and clinical studies have showed beneficial outcomes after myocardial infarction. In this review, the current understanding of stem cell therapy in preclinical and clinical experiences is summarized. Stem cells from bone marrow have shown a potential to improve cardiac performance after myocardial infarction in animal and early clinical studies. Clinical trials from all over the world have provided safety assessments of stem cell therapy with marginal improvement of clinical outcomes. Thus, further investigations should be encouraged to resolve the discrepancies between studies, clinical issues, and unclear translational findings. This review provides information and commentary on key trials for stem cell-based treat-ment of cardiovascular disease. The Korean Society of Cardiology 2012-02 2012-02-27 /pmc/articles/PMC3291729/ /pubmed/22396692 http://dx.doi.org/10.4070/kcj.2012.42.2.71 Text en Copyright © 2012 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kim, Yong Sook Ahn, Youngkeun A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials |
title | A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials |
title_full | A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials |
title_fullStr | A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials |
title_full_unstemmed | A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials |
title_short | A Long Road for Stem Cells to Cure Sick Hearts: Update on Recent Clinical Trials |
title_sort | long road for stem cells to cure sick hearts: update on recent clinical trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291729/ https://www.ncbi.nlm.nih.gov/pubmed/22396692 http://dx.doi.org/10.4070/kcj.2012.42.2.71 |
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