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Autoimmune Myasthenia Gravis after Sternal Fracture

We report a 54-year-old woman who suffered a commotio cerebri, whiplash injury and a chest trauma with sternal fracture due to a high-velocity car accident. Two months later, she developed unilateral ptosis and blurred vision, which worsened during the day. Multiple diagnoses were suggested, ranging...

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Autores principales: Petersen, Jens A., Jung, Hans H., Weller, Michael, Linnebank, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291889/
https://www.ncbi.nlm.nih.gov/pubmed/22393321
http://dx.doi.org/10.1159/000335992
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author Petersen, Jens A.
Jung, Hans H.
Weller, Michael
Linnebank, Michael
author_facet Petersen, Jens A.
Jung, Hans H.
Weller, Michael
Linnebank, Michael
author_sort Petersen, Jens A.
collection PubMed
description We report a 54-year-old woman who suffered a commotio cerebri, whiplash injury and a chest trauma with sternal fracture due to a high-velocity car accident. Two months later, she developed unilateral ptosis and blurred vision, which worsened during the day. Multiple diagnoses were suggested, ranging from thoracic outlet syndrome towards depression. Symptoms persisted and five years later, the patient consulted a neurologist. Laboratory analysis revealed significantly elevated levels of antibodies to acetylcholine receptors, and the diagnosis of myasthenia gravis was made. Speculatively, the damage of retrosternal thymic remnants due to a sternal fracture might have precipitated the condition or exacerbated subclinical disease.
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spelling pubmed-32918892012-03-05 Autoimmune Myasthenia Gravis after Sternal Fracture Petersen, Jens A. Jung, Hans H. Weller, Michael Linnebank, Michael Case Rep Neurol Published: January, 2012 We report a 54-year-old woman who suffered a commotio cerebri, whiplash injury and a chest trauma with sternal fracture due to a high-velocity car accident. Two months later, she developed unilateral ptosis and blurred vision, which worsened during the day. Multiple diagnoses were suggested, ranging from thoracic outlet syndrome towards depression. Symptoms persisted and five years later, the patient consulted a neurologist. Laboratory analysis revealed significantly elevated levels of antibodies to acetylcholine receptors, and the diagnosis of myasthenia gravis was made. Speculatively, the damage of retrosternal thymic remnants due to a sternal fracture might have precipitated the condition or exacerbated subclinical disease. S. Karger AG 2012-01-20 /pmc/articles/PMC3291889/ /pubmed/22393321 http://dx.doi.org/10.1159/000335992 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: January, 2012
Petersen, Jens A.
Jung, Hans H.
Weller, Michael
Linnebank, Michael
Autoimmune Myasthenia Gravis after Sternal Fracture
title Autoimmune Myasthenia Gravis after Sternal Fracture
title_full Autoimmune Myasthenia Gravis after Sternal Fracture
title_fullStr Autoimmune Myasthenia Gravis after Sternal Fracture
title_full_unstemmed Autoimmune Myasthenia Gravis after Sternal Fracture
title_short Autoimmune Myasthenia Gravis after Sternal Fracture
title_sort autoimmune myasthenia gravis after sternal fracture
topic Published: January, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291889/
https://www.ncbi.nlm.nih.gov/pubmed/22393321
http://dx.doi.org/10.1159/000335992
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