The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Lu, Hong, Xu, Yingzhi, Hu, Xiaofeng, Chen, Wei, Li, Shang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292010/
https://www.ncbi.nlm.nih.gov/pubmed/22408441
http://dx.doi.org/10.3390/ijms13022110
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author Wang, Jing
Lu, Hong
Xu, Yingzhi
Hu, Xiaofeng
Chen, Wei
Li, Shang
author_facet Wang, Jing
Lu, Hong
Xu, Yingzhi
Hu, Xiaofeng
Chen, Wei
Li, Shang
author_sort Wang, Jing
collection PubMed
description In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
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spelling pubmed-32920102012-03-09 The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis Wang, Jing Lu, Hong Xu, Yingzhi Hu, Xiaofeng Chen, Wei Li, Shang Int J Mol Sci Article In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU. Molecular Diversity Preservation International (MDPI) 2012-02-16 /pmc/articles/PMC3292010/ /pubmed/22408441 http://dx.doi.org/10.3390/ijms13022110 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Jing
Lu, Hong
Xu, Yingzhi
Hu, Xiaofeng
Chen, Wei
Li, Shang
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_full The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_fullStr The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_full_unstemmed The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_short The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_sort effect of toll-like receptor 4 in the aqueous humor of endotoxin-induced uveitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292010/
https://www.ncbi.nlm.nih.gov/pubmed/22408441
http://dx.doi.org/10.3390/ijms13022110
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