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Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292018/ https://www.ncbi.nlm.nih.gov/pubmed/22408449 http://dx.doi.org/10.3390/ijms13022219 |
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author | Pohanka, Miroslav |
author_facet | Pohanka, Miroslav |
author_sort | Pohanka, Miroslav |
collection | PubMed |
description | Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer’s disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of α7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer’s disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the α7 nAChR. Pharmacological, toxicological, and medicinal significance of α7 nAChR are discussed throughout this paper. |
format | Online Article Text |
id | pubmed-3292018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32920182012-03-09 Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology Pohanka, Miroslav Int J Mol Sci Review Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer’s disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of α7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer’s disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the α7 nAChR. Pharmacological, toxicological, and medicinal significance of α7 nAChR are discussed throughout this paper. Molecular Diversity Preservation International (MDPI) 2012-02-17 /pmc/articles/PMC3292018/ /pubmed/22408449 http://dx.doi.org/10.3390/ijms13022219 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Pohanka, Miroslav Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology |
title | Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology |
title_full | Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology |
title_fullStr | Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology |
title_full_unstemmed | Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology |
title_short | Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology |
title_sort | alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292018/ https://www.ncbi.nlm.nih.gov/pubmed/22408449 http://dx.doi.org/10.3390/ijms13022219 |
work_keys_str_mv | AT pohankamiroslav alpha7nicotinicacetylcholinereceptorisatargetinpharmacologyandtoxicology |