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Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering

A new detection technique called Fast Fourier Transform Square-Wave Voltammetry (FFT SWV) is based on measurements of electrode admittance as a function of potential. The response of the detector (microelectrode), which is generated by a redox processes, is fast, which makes the method suitable for...

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Autores principales: Daneshgar, Parandis, Norouzi, Parviz, Ganjali, Mohammad Reza, Dinarvand, Rasoul, Moosavi-Movahedi, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292088/
https://www.ncbi.nlm.nih.gov/pubmed/22408485
http://dx.doi.org/10.3390/s91007903
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author Daneshgar, Parandis
Norouzi, Parviz
Ganjali, Mohammad Reza
Dinarvand, Rasoul
Moosavi-Movahedi, Ali Akbar
author_facet Daneshgar, Parandis
Norouzi, Parviz
Ganjali, Mohammad Reza
Dinarvand, Rasoul
Moosavi-Movahedi, Ali Akbar
author_sort Daneshgar, Parandis
collection PubMed
description A new detection technique called Fast Fourier Transform Square-Wave Voltammetry (FFT SWV) is based on measurements of electrode admittance as a function of potential. The response of the detector (microelectrode), which is generated by a redox processes, is fast, which makes the method suitable for most applications involving flowing electrolytes. The carbon paste electrode was modified by nanostructures to improve sensitivity. Synthesized dysprosium nanowires provide a more effective nanotube-like surface [1-4] so they are good candidates for use as a modifier for electrochemical reactions. The redox properties of diclofenac were used for its determination in human serum and urine samples. The support electrolyte that provided a more defined and intense peak current for diclofenac determination was a 0.05 mol L(−1) acetate buffer pH = 4.0. The drug presented an irreversible oxidation peak at 850 mV vs. Ag/AgCl on a modified nanowire carbon paste electrode which produced high current and reduced the oxidation potential by about 100 mV. Furthermore, the signal-to-noise ratio was significantly increased by application of a discrete Fast Fourier Transform (FFT) method, background subtraction and two-dimensional integration of the electrode response over a selected potential range and time window. To obtain the much sensivity the effective parameters such as frequency, amplitude and pH was optimized. As a result, C(DL) of 2.0 × 10(−9) M and an LOQ of 5.0 × 10(−9) M were found for the determination for diclofenac. A good recovery was obtained for assay spiked urine samples and a good quantification of diclofenac was achieved in a commercial formulation.
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spelling pubmed-32920882012-03-09 Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering Daneshgar, Parandis Norouzi, Parviz Ganjali, Mohammad Reza Dinarvand, Rasoul Moosavi-Movahedi, Ali Akbar Sensors (Basel) Article A new detection technique called Fast Fourier Transform Square-Wave Voltammetry (FFT SWV) is based on measurements of electrode admittance as a function of potential. The response of the detector (microelectrode), which is generated by a redox processes, is fast, which makes the method suitable for most applications involving flowing electrolytes. The carbon paste electrode was modified by nanostructures to improve sensitivity. Synthesized dysprosium nanowires provide a more effective nanotube-like surface [1-4] so they are good candidates for use as a modifier for electrochemical reactions. The redox properties of diclofenac were used for its determination in human serum and urine samples. The support electrolyte that provided a more defined and intense peak current for diclofenac determination was a 0.05 mol L(−1) acetate buffer pH = 4.0. The drug presented an irreversible oxidation peak at 850 mV vs. Ag/AgCl on a modified nanowire carbon paste electrode which produced high current and reduced the oxidation potential by about 100 mV. Furthermore, the signal-to-noise ratio was significantly increased by application of a discrete Fast Fourier Transform (FFT) method, background subtraction and two-dimensional integration of the electrode response over a selected potential range and time window. To obtain the much sensivity the effective parameters such as frequency, amplitude and pH was optimized. As a result, C(DL) of 2.0 × 10(−9) M and an LOQ of 5.0 × 10(−9) M were found for the determination for diclofenac. A good recovery was obtained for assay spiked urine samples and a good quantification of diclofenac was achieved in a commercial formulation. Molecular Diversity Preservation International (MDPI) 2009-09-30 /pmc/articles/PMC3292088/ /pubmed/22408485 http://dx.doi.org/10.3390/s91007903 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Daneshgar, Parandis
Norouzi, Parviz
Ganjali, Mohammad Reza
Dinarvand, Rasoul
Moosavi-Movahedi, Ali Akbar
Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering
title Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering
title_full Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering
title_fullStr Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering
title_full_unstemmed Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering
title_short Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering
title_sort determination of diclofenac on a dysprosium nanowire- modified carbon paste electrode accomplished in a flow injection system by advanced filtering
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292088/
https://www.ncbi.nlm.nih.gov/pubmed/22408485
http://dx.doi.org/10.3390/s91007903
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