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Design Strategies for Aptamer-Based Biosensors
Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292130/ https://www.ncbi.nlm.nih.gov/pubmed/22399891 http://dx.doi.org/10.3390/s100504541 |
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author | Han, Kun Liang, Zhiqiang Zhou, Nandi |
author_facet | Han, Kun Liang, Zhiqiang Zhou, Nandi |
author_sort | Han, Kun |
collection | PubMed |
description | Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications. |
format | Online Article Text |
id | pubmed-3292130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-32921302012-03-07 Design Strategies for Aptamer-Based Biosensors Han, Kun Liang, Zhiqiang Zhou, Nandi Sensors (Basel) Review Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications. Molecular Diversity Preservation International (MDPI) 2010-05-04 /pmc/articles/PMC3292130/ /pubmed/22399891 http://dx.doi.org/10.3390/s100504541 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Han, Kun Liang, Zhiqiang Zhou, Nandi Design Strategies for Aptamer-Based Biosensors |
title | Design Strategies for Aptamer-Based Biosensors |
title_full | Design Strategies for Aptamer-Based Biosensors |
title_fullStr | Design Strategies for Aptamer-Based Biosensors |
title_full_unstemmed | Design Strategies for Aptamer-Based Biosensors |
title_short | Design Strategies for Aptamer-Based Biosensors |
title_sort | design strategies for aptamer-based biosensors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292130/ https://www.ncbi.nlm.nih.gov/pubmed/22399891 http://dx.doi.org/10.3390/s100504541 |
work_keys_str_mv | AT hankun designstrategiesforaptamerbasedbiosensors AT liangzhiqiang designstrategiesforaptamerbasedbiosensors AT zhounandi designstrategiesforaptamerbasedbiosensors |