Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

OBJECTIVE: Leptin therapy has been found to reverse hyperglycemia and prevent mortality in several rodent models of type 1 diabetes. Yet the mechanism of leptin-mediated reversal of hyperglycemia has not been fully defined. The liver is a key organ regulating glucose metabolism and is also a target...

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Detalles Bibliográficos
Autores principales: Denroche, Heather C., Levi, Jasna, Wideman, Rhonda D., Sequeira, Roveena M., Huynh, Frank K., Covey, Scott D., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292314/
https://www.ncbi.nlm.nih.gov/pubmed/21464443
http://dx.doi.org/10.2337/db10-0958

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