Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice

OBJECTIVE: ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and functio...

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Detalles Bibliográficos
Autores principales: Sloan, Crystal, Tuinei, Joseph, Nemetz, Katherine, Frandsen, Jonathan, Soto, Jamie, Wride, Noah, Sempokuya, Tomoki, Alegria, Luis, Bugger, Heiko, Abel, E. Dale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292315/
https://www.ncbi.nlm.nih.gov/pubmed/21441440
http://dx.doi.org/10.2337/db10-1106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292315/
https://www.ncbi.nlm.nih.gov/pubmed/21441440
http://dx.doi.org/10.2337/db10-1106

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