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Spectrum of gluten-related disorders: consensus on new nomenclature and classification
A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interestin...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292448/ https://www.ncbi.nlm.nih.gov/pubmed/22313950 http://dx.doi.org/10.1186/1741-7015-10-13 |
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author | Sapone, Anna Bai, Julio C Ciacci, Carolina Dolinsek, Jernej Green, Peter HR Hadjivassiliou, Marios Kaukinen, Katri Rostami, Kamran Sanders, David S Schumann, Michael Ullrich, Reiner Villalta, Danilo Volta, Umberto Catassi, Carlo Fasano, Alessio |
author_facet | Sapone, Anna Bai, Julio C Ciacci, Carolina Dolinsek, Jernej Green, Peter HR Hadjivassiliou, Marios Kaukinen, Katri Rostami, Kamran Sanders, David S Schumann, Michael Ullrich, Reiner Villalta, Danilo Volta, Umberto Catassi, Carlo Fasano, Alessio |
author_sort | Sapone, Anna |
collection | PubMed |
description | A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications. |
format | Online Article Text |
id | pubmed-3292448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32924482012-03-03 Spectrum of gluten-related disorders: consensus on new nomenclature and classification Sapone, Anna Bai, Julio C Ciacci, Carolina Dolinsek, Jernej Green, Peter HR Hadjivassiliou, Marios Kaukinen, Katri Rostami, Kamran Sanders, David S Schumann, Michael Ullrich, Reiner Villalta, Danilo Volta, Umberto Catassi, Carlo Fasano, Alessio BMC Med Opinion A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications. BioMed Central 2012-02-07 /pmc/articles/PMC3292448/ /pubmed/22313950 http://dx.doi.org/10.1186/1741-7015-10-13 Text en Copyright ©2012 Sapone et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Opinion Sapone, Anna Bai, Julio C Ciacci, Carolina Dolinsek, Jernej Green, Peter HR Hadjivassiliou, Marios Kaukinen, Katri Rostami, Kamran Sanders, David S Schumann, Michael Ullrich, Reiner Villalta, Danilo Volta, Umberto Catassi, Carlo Fasano, Alessio Spectrum of gluten-related disorders: consensus on new nomenclature and classification |
title | Spectrum of gluten-related disorders: consensus on new nomenclature and classification |
title_full | Spectrum of gluten-related disorders: consensus on new nomenclature and classification |
title_fullStr | Spectrum of gluten-related disorders: consensus on new nomenclature and classification |
title_full_unstemmed | Spectrum of gluten-related disorders: consensus on new nomenclature and classification |
title_short | Spectrum of gluten-related disorders: consensus on new nomenclature and classification |
title_sort | spectrum of gluten-related disorders: consensus on new nomenclature and classification |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292448/ https://www.ncbi.nlm.nih.gov/pubmed/22313950 http://dx.doi.org/10.1186/1741-7015-10-13 |
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