Serotonin-mediated modulation of Na(+)/K(+ )pump current in rat hippocampal CA1 pyramidal neurons

BACKGROUND: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na(+)/K(+ )pump in rat hippocampal CA1 pyramidal neurons. RESULTS: 5-HT (0.1, 1 mM) showed Na(+)/K(+ )pump current (Ip) densities of 0.40 ± 0.04, 0.34 ± 0.03 pA/pF contrast to 0.63 ± 0.04...

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Detalles Bibliográficos
Autores principales: Zhang, Li Nan, Su, Su Wen, Guo, Fang, Guo, Hui Cai, Shi, Xiao Lu, Li, Wen Ya, Liu, Xu, Wang, Yong Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292479/
https://www.ncbi.nlm.nih.gov/pubmed/22257758
http://dx.doi.org/10.1186/1471-2202-13-10
Descripción
Sumario:BACKGROUND: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na(+)/K(+ )pump in rat hippocampal CA1 pyramidal neurons. RESULTS: 5-HT (0.1, 1 mM) showed Na(+)/K(+ )pump current (Ip) densities of 0.40 ± 0.04, 0.34 ± 0.03 pA/pF contrast to 0.63 ± 0.04 pA/pF of the control of 0.5 mM strophanthidin (Str), demonstrating 5-HT-induced inhibition of Ip in a dose-dependent manner in hippocampal CA1 pyramidal neurons. The effect was partly attenuated by ondasetron, a 5-HT(3 )receptor (5-HT(3)R) antagonist, not by WAY100635, a 5-HT(1A)R antagonist, while 1-(3-Chlorophenyl) biguanide hydrochloride (m-CPBG), a 5-HT(3)R specific agonist, mimicked the effect of 5-HT on Ip. CONCLUSION: 5-HT inhibits neuronal Na(+)/K(+ )pump activity via 5-HT(3)R in rat hippocampal CA1 pyramidal neurons. This discloses novel mechanisms for the function of 5-HT in learning and memory, which may be a useful target to benefit these patients with cognitive disorder.

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