Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases

Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in man...

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Autores principales: Ching, Alex Sik Chung, Kuhnast, Bertrand, Damont, Annelaure, Roeda, Dirk, Tavitian, Bertrand, Dollé, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292648/
https://www.ncbi.nlm.nih.gov/pubmed/22696004
http://dx.doi.org/10.1007/s13244-011-0128-x
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author Ching, Alex Sik Chung
Kuhnast, Bertrand
Damont, Annelaure
Roeda, Dirk
Tavitian, Bertrand
Dollé, Frédéric
author_facet Ching, Alex Sik Chung
Kuhnast, Bertrand
Damont, Annelaure
Roeda, Dirk
Tavitian, Bertrand
Dollé, Frédéric
author_sort Ching, Alex Sik Chung
collection PubMed
description Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may constitute a biomarker for brain inflammation that could be monitored by using TSPO tracers as neuroimaging agents. From medical imaging perspectives, this review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative diseases in humans.
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spelling pubmed-32926482012-03-16 Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases Ching, Alex Sik Chung Kuhnast, Bertrand Damont, Annelaure Roeda, Dirk Tavitian, Bertrand Dollé, Frédéric Insights Imaging Review Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may constitute a biomarker for brain inflammation that could be monitored by using TSPO tracers as neuroimaging agents. From medical imaging perspectives, this review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative diseases in humans. Springer-Verlag 2011-10-16 /pmc/articles/PMC3292648/ /pubmed/22696004 http://dx.doi.org/10.1007/s13244-011-0128-x Text en © European Society of Radiology 2011
spellingShingle Review
Ching, Alex Sik Chung
Kuhnast, Bertrand
Damont, Annelaure
Roeda, Dirk
Tavitian, Bertrand
Dollé, Frédéric
Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
title Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
title_full Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
title_fullStr Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
title_full_unstemmed Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
title_short Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
title_sort current paradigm of the 18-kda translocator protein (tspo) as a molecular target for pet imaging in neuroinflammation and neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292648/
https://www.ncbi.nlm.nih.gov/pubmed/22696004
http://dx.doi.org/10.1007/s13244-011-0128-x
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