Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway

BACKGROUND: In addition to their central effects, opioids cause peripheral analgesia. There is evidence showing that peripheral activation of kappa opioid receptors (KORs) inhibits inflammatory pain. Moreover, peripheral μ-opioid receptor (MOR) activation are able to direct block PGE(2)-induced ongo...

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Detalles Bibliográficos
Autores principales: Cunha, Thiago M, Souza, Guilherme R, Domingues, Andressa C, Carreira, Eleonora U, Lotufo, Celina M, Funez, Mani I, Verri, Waldiceu A, Cunha, Fernando Q, Ferreira, Sergio H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293001/
https://www.ncbi.nlm.nih.gov/pubmed/22316281
http://dx.doi.org/10.1186/1744-8069-8-10

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