IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci

BACKGROUND: Murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, presents typically as ascending paralysis. However, in mice in which interferon-gamma (IFNγ) signaling is disrupted by genetic deletion, limb paralysis is accompanied by atypical deficits, including h...

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Detalles Bibliográficos
Autores principales: Lee, Eunyoung, Chanamara, Sarah, Pleasure, David, Soulika, Athena M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293042/
https://www.ncbi.nlm.nih.gov/pubmed/22248039
http://dx.doi.org/10.1186/1742-2094-9-7

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